President:
Pres: John Tyler
Pres: James K. Polk inaugurated
General
- Culture: John Chapman (Johnny Appleseed) dies
- Medicine: J Marion Sims "father of gynecology" experiments on enslaved African women without anesthesia
- Transportation: Work on railroads resumes
Eruption and mudflow at Nevado del Ruiz, , , *
East
- Maryland: US Naval Academy opened in Annapolis
- Massachusetts: Macon Allen – first African lawyer
- New York: New York Knickerbocker Club forms as first basketball organization - rules codified
Midwest
- Illinois: Citizens request Mormons leave
- Wisconsin: Milwaukee Bridge War
South
- Florida: Statehood as #27
- Texas: Disenfranchisement of blacks
Texas voluntarily annexed to the US – admitted as state which triggers Mexican-American War
Statehood #28
West and Pacific