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General

Population: Between 190 and 230 million*

• History: Quintus Gabius Pictor becomes first Roman historians (225 BC)
• Deaths: Ptolemy III of Egypt (221 BC)

Africa

• Egypt: Death of Ptolemy III (221 BC)
  Ptolemy IV Philopater rules (221 BC)

Asia

• China: Zheng the king of Qin adopts title of Qin Shi Huang-di (Zheng) the first emperor of China (221 BC)
  End of Era of Warring States and start of Ch'in (Qin) Dynasty to 207 BC (221 BC)
  Unification of CHinese weights and measures (221 BC)
  First Great Wall built to keep out the Xiongnu and Zheng people (221 BC)

Europe

• General: Earliest known Celtic coinage (225 BC)
• Gaul: Romans defeat Gauls at battle of Telamon in Eturia (225 BC)
  End of Gisalpine Gaul with 5000 dead (222 BC)
• Greece: Alexander destroys Thebes (225 BC)
  Earthquake at Rhodes - Colossus and city of Kameiros destroyed (226 or 224 BC)
  Antigonus III Doson of Macedonia takes possession of Sparta (222 BC)
  Philip V rules Macedonia (221 BC)
• Roman Empire: First Roman ambassadors in Athens and Corinth (228 BC)
  Romans defeat Celts at Telamon in Italy (225 BC)
  Rome conquers north Italy including Mediolanum (Milan) (222 BC)
  Creation of Flaminian Way between Rome and Rimini (220 BC)
• Spanish States: Carthago Nova (Cartagena) founded by Hasdrubal (228 BC)

Middle East

• Mesopotamia: Antiochus III the Great rules Babylonian Empire (223 BC)